Levosimendan in Pulmonary Hypertension

Clinical Studies

  • 2017– Jiang, Rong, et al. “Efficacy and Safety of a Calcium Sensitizer, Levosimendan, in Patients with Right Heart Failure due to Pulmonary Hypertension.” The Clinical Respiratory Journal(2017).
  • 2016 -Guerrero-Orriach, José Luis, et al. “Cardiac, renal, and neurological benefits of preoperative levosimendan administration in patients with right ventricular dysfunction and pulmonary hypertension undergoing cardiac surgery: evaluation with two biomarkers neutrophil gelatinase-associated lipocalin and neuronal enolase.” Therapeutics and clinical risk management12 (2016): 623
  • 2012– Martyniuk TV, Arkhipova OA, Kobal’ EA, Danilov NM, Chazova IE. Possibilities of using levosimendan in patients with idiopathic pulmonary hypertension.  Ter Arkh. 2012;84(9):83-8.
  • 2009 -Kleber, Franz X., et al. “Repetitive dosing of intravenous levosimendan improves pulmonary hemodynamics in patients with pulmonary hypertension: results of a pilot study.” The Journal of Clinical Pharmacology49.1 (2009): 109-115.

Preclinical Studies

  • 2018- Hansen, M. S., et al. “Levosimendan improves cardiac function and myocardial efficiency in rats with right ventricular failure.” Pulmonary circulation8.1 (2018): 2045893217743122-2045893217743122
  • 2017– Hansen, Mona Sahlholdt, et al. “Levosimendan prevents and reverts right ventricular failure in experimental pulmonary arterial hypertension.” Journal of Cardiovascular Pharmacology(2017).
  • 2017- Tavares-Silva, Marta, et al. “Dose–Response Head-to-Head Comparison of Inodilators Dobutamine, Milrinone, and Levosimendan in Chronic Experimental Pulmonary Hypertension.” Journal of Cardiovascular Pharmacology and Therapeutics(2017): 1074248417696818.
  • 2012– Wiklund, Annaeva, David Kylhammar, and Göran Rådegran. “Levosimendan attenuates hypoxia-induced pulmonary hypertension in a porcine model.” Journal of cardiovascular pharmacology59.5 (2012): 441-449.
  • 2011– Revermann, M., et al. “Levosimendan attenuates pulmonary vascular remodeling.” Intensive care medicine37.8 (2011): 1368-1377.